{"title":"Integrative Therapeutics®","description":"\u003cspan data-mce-fragment=\"1\"\u003eMake every moment count with science-based supplements that support optimal wellness, previously available only through practitioners.\u003c\/span\u003e","products":[{"product_id":"active-b-complex","title":"Active B-Complex","description":"\u003cp\u003eB-VITAMINS PLAY ESSENTIAL ROLES IN MANY FUNCTIONS OF THE BODY\u003c\/p\u003e\u003cp\u003eOptimal folate and B vitamin intakes are associated with healthy neurological function as well as cardiovascular support.*\u003csup\u003e1,2\u003c\/sup\u003e Each B-vitamin exists in multiple forms, often referred to as vitamers. Active forms of vitamers are those that can be directly utilized by the body immediately. Active B-Complex features a potent blend containing the active forms of Vitamins B2, B6, B12, as well as Quatrefolic®-branded methylfolate (the bioactive form of folate). Free from top 8 allergens.\u003c\/p\u003e\u003cp\u003eHOW IT WORKS\u003c\/p\u003e\u003cp\u003eB-vitamins play essential roles in many functions of the body. Vitamin B1 (as Thiamin) and Vitamin B2 (Riboflavin as riboflavin-5'-phosphate) serve as coenzymes essential for cell function, growth and energy production.*\u003csup\u003e1\u003c\/sup\u003e Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl) has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).*\u003csup\u003e3 \u003c\/sup\u003eFolate has essential roles in nervous system and immune system function.*\u003csup\u003e1,4\u003c\/sup\u003e Vitamin B12 (as methylcobalamin) is essential for nervous system function, playing particular roles in myelin synthesis and nerve metabolism.*\u003csup\u003e5\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eKennedy DO et al. Nutrients. 2016;8(2):68.\u003c\/li\u003e\n\u003cli\u003eWald DS et al. BMJ. 2002;325(7374):1202. \u003c\/li\u003e\n\u003cli\u003eStover PJ et al. Adv Nutr. 2015;6(1):132-3. \u003c\/li\u003e\n\u003cli\u003eMaggini S et al. Nutrients. 2018;10(10):1531. \u003c\/li\u003e\n\u003cli\u003eCalderon-Ospina CA et al. CNS Neurosci Ther. 2020;26(1):5-13. \u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/small\u003e","brand":"ITI","offers":[{"title":"60 capsules","offer_id":43405102448854,"sku":"10032","price":18.25,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/9110\/4982\/files\/202603111927_67993b1f-4821-4e6f-b177-8ba30eb22736.png?v=1776809790"},{"product_id":"cortisol-manager","title":"Cortisol Manager®","description":"\u003cp\u003eThe ingredients in Cortisol Manager support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager also promotes relaxation to support restful sleep.*\u003c\/p\u003e\u003cp\u003eTHE ROLE OF CORTISOL IN TIMES OF STRESS\u003c\/p\u003e\u003cp\u003eCortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact.\u003c\/p\u003e\u003cp\u003eWITH HERBAL INGREDIENTS\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) and L-theanine.* A proprietary blend of Magnolia (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e) and epimedium (\u003cem\u003eEpimedium koreanum\u003c\/em\u003e), as well as phosphatidylserine from soy lecithin are included in Cortisol Manager.\u003c\/p\u003e\u003cp\u003eA 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*\u003csup\u003e1\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager help support relaxation to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eAuddy B et al. J Am Nutraceutical Assoc. 2008;11(1):50-6.\u003c\/li\u003e\n\u003cli\u003eNobre AC et al. 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Nat Med. 2004;10(12):1344-51.\u003c\/li\u003e\n\u003cli\u003e Yin J et al. Metabolism. 2008;57(5):712-7.\u003c\/li\u003e\n\u003cli\u003e Zhang Y et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565.\u003c\/li\u003e\n\u003cli\u003e Yang J et al. Evid Based Complement Alternat Med. 2012;2012:363845.\u003c\/li\u003e\n\u003cli\u003e Perez-Rubio K et al. Metab Syndr Relat Disord. 2013;11(5):366-9.\u003c\/li\u003e\n\u003cli\u003e  Cao C et al. Exp Ther Med. 2019;17(4):3009-3014.\u003c\/li\u003e\n\u003cli\u003e Lee YS et al. Diabetes. 2006;55:2256-64.\u003c\/li\u003e\n\u003cli\u003eBrusq JM et al. J Lipid Res. 2006;47(6):1281-8.\u003c\/li\u003e\n\u003cli\u003e Jiang D et al. Lipids Health Dis. 2016;15:214.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/small\u003e","brand":"ITI","offers":[{"title":"60 capsules","offer_id":44397803897046,"sku":"10711","price":32.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/9110\/4982\/files\/202603111926_583240e8-97da-42dc-a8e4-f2df23cda5ce.png?v=1776810274"},{"product_id":"hpa-adapt","title":"HPA Adapt™","description":"\u003cp\u003eWHAT IT DOES\u003c\/p\u003e\u003cp\u003eHPA ADAPT HELPS SUPPORT THE BODY IN TIMES OF STRESS*\u003c\/p\u003e\u003cp\u003ePowerful adaptogenic herbs are combined to improve mood, create calm, reduce stress-related fatigue, and support cognitive function.* By supporting homeostasis along the hypothalamic-pituitary-adrenal (HPA) axis, HPA Adapt helps maintain stress hormonal balance and a healthy stress response.*\u003c\/p\u003e\u003cp\u003eHOW IT WORKS\u003c\/p\u003e\u003cp\u003eOPTIMIZING HPA AXIS FUNCTION*\u003c\/p\u003e\u003cp\u003eThe body has a built-in system known as the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis helps maintain hormonal homeostasis even during times of mental, emotional, and\/or physical stress. The HPA axis is designed to balance mood, energy levels, and cognition.*\u003csup\u003e1\u003c\/sup\u003e Evidence from animal studies shows the HPA axis also helps support neurological, gastrointestinal, and immune function, suggesting it may influence other internal systems as the body copes with stress.*\u003csup\u003e2\u003c\/sup\u003e By influencing HPA axis function, HPA Adapt is formulated to support stress hormone balance and a healthy stress response.*\u003csup\u003e3\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eADAPTOGENIC HERBS HELP MAINTAIN STRESS HORMONAL BALANCE*\u003c\/p\u003e\u003cp\u003eHPA Adapt contains Rhodiola root extract, SENSORIL® Ashwagandha root and leaf extract, eleuthero root extract, maca standardized extract, and standardized holy basil leaf extract. This formulation was designed to:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eImprove mood*\u003c\/li\u003e\n\u003cli\u003eCreate calm*\u003c\/li\u003e\n\u003cli\u003eReduce stress-related fatigue*\u003c\/li\u003e\n\u003cli\u003eSupport cognitive function*\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eKeller J et al. Molecular Psychiatry. 2017;22(4):527-536. \u003c\/li\u003e\n\u003cli\u003eFarzi A, et al. Neurotherapeutics. 2018;15(1):5-22.\u003c\/li\u003e\n\u003cli\u003eAuddy, B, et al. JANA Vol. 11, No. 1, 2008: 50-56.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/small\u003e","brand":"ITI","offers":[{"title":"120 capsules","offer_id":47745162576086,"sku":"10270","price":39.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0666\/9110\/4982\/files\/202603111926_c75772f7-f2da-45b9-b9f9-edd40dbe115c.png?v=1776806987"},{"product_id":"theracurmin-hp","title":"Theracurmin® HP","description":"\u003cp\u003eTheracurmin® is a novel preparation of turmeric that utilizes patented, colloidal dispersion technology to enhance bioavailability and dramatically increase curcumin levels in the blood.*1\u003c\/p\u003e\u003cp\u003eUnlike other forms of curcumin, Theracurmin is water-dispersible, thereby improving curcumin's overall absorption.\u003c\/p\u003e\u003cp\u003eHOW IT WORKS\u003c\/p\u003e\u003cp\u003eTHERACURMIN® IS OVER 27 TIMES MORE BIOAVAILABLE THAN STANDARD CURCUMIN EXTRACTS\u003c\/p\u003e\u003cp\u003eStandard curcumin is poorly absorbed even at high doses. Human clinical trials show that Theracurmin® is over 27 times more bioavailable than a standard curcumin extract and is many times more bioavailable than other commercially-available curcumin supplements.1,2 Theracurmin® has been clinically shown to support detoxification pathways, healthy cardiovascular function, muscle recovery after acute exercise and provide relief of minor pain due to occasional overuse.*\u003csup\u003e1,3-5\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eBIOLOGICAL EFFECTS OF CURCUMIN\u003c\/p\u003e\u003cp\u003eIn vitro and in vivo research demonstrates that curcumin supports detoxification and cytokine pathways.*\u003csup\u003e6,7\u003c\/sup\u003e While mechanisms of action are still under investigation, the chemical structure of curcumin directly influences antioxidant pathways, with its phenolic hydroxyl group behaving as an electron donor.\u003csup\u003e7\u003c\/sup\u003e Based on in vitro and in vivo studies, curcumin's indirect effects on antioxidant pathways include modulating cellular redox homeostasis and enhancing the activity of antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase, enzymes that also support detoxification and cytokine pathways.\u003csup\u003e7\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eSasaki H et al. Biol Pharm Bull. 2011;34(5):660-5.\u003c\/li\u003e\n\u003cli\u003e Sunagawa Y et al. J Nutr Sci Vitaminol. 2015;61:37-44.\u003c\/li\u003e\n\u003cli\u003eAkazawa N et al. Nutr Res. 2012;32(10):797-9.\u003c\/li\u003e\n\u003cli\u003eTanabe Y et al. Eur J Appl Physiol. 2015;115(9):1949-57.\u003c\/li\u003e\n\u003cli\u003eNakagawa Y et al. J Orthop Sci. 2014;19:933-9. \u003c\/li\u003e\n\u003cli\u003eGupta SC et al. Clin Exp Pharmacol Physiol. 2012;39(3):283-99.\u003c\/li\u003e\n\u003cli\u003eXu XY et al. 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